CONJUGUES ANTICORPS-ANTIGENE LIES PAR COVALENCE

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

BENZ, JOERG,BRINKMANN, ULRICH,DENGL, STEFAN,DZIADEK, SEBASTIAN,GEORGES, GUY,GROTE, MICHAEL,HAAS, ALEXANDER,HOFFMANN, EIKE

申请号：

CA2871112

公开号：

CA2871112A1

申请日:

2013.07.04

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

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