596292 A highly reliable ingestible event marker comprises a circuitry element. The circuitry element comprises a control circuit comprising an upper surface and a lower surface； a first electrochemical material defining a first outer perimeter edge, a second electrochemical material defining a second outer perimeter edge and a membrane. The first electrochemical material is electrically-coupled to the upper surface of the control circuit. The second electrochemical material is electrically-coupled to the lower surface of the control circuit, and the first and second electrochemical materials are electrically-isolated from each other and are configured to generate a voltage potential difference to power the control circuit. The membrane comprises an insulating material positioned between the first and second electrochemical materials. The insulating material comprises a third outer edge extending beyond the first outer perimeter edge of the first electrochemical material and the second outer perimeter edge of the second electrochemical material to thereby increase a length of a current path between the first electrochemical material and the second electrochemical material. The current path is defined through an electrically-conductive liquid in a body and is configured to route a conductively-transmitted signal generated by the circuitry element to a receiver spaced apart from the circuitry element. A system comprising the highly reliable ingestible event marker is further disclosed. The system can further comprises a communication detection component or at least one receiver configured to receive a conductively-transmitted signal from the highly reliable ingestible event marker, and the conductively-transmitted signal is generated by the circuitry element of the highly reliable ingestible event marker.
