Disclosed herein is a topical composition that contains (a) a plant meristem conditioned nutrient medium derived from the plants of the genus Oryza； (b) a preservative present at an amount sufficient to provide sterilizing or biostatic efficacy with respect to component (a)； and (c) a dermatologically acceptable vehicle. When topically applied to mammalian cells, the composition of the invention can influence the epigenetic methylation of the DNA such that the methylation state is modulated to have more characteristics and patterns of the epigenetic state of younger cells.
