P. Jeffrey Conn,Craig W. Lindsley,Kyle A. Emmitte,Andrew S. Felts,Katrina A. Bollinger
申请号：
US15558788
公开号：
US10538491B2
申请日:
2016.03.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
4,5-Substituted Picolinamide and picolinonitrile compounds of formula (I), where R4 is CONH2 or CN and R1 is an optionally substituted aryl or heteroaryl, are negative allosteric modulators of the metabotropic glutamate receptor 2 (mGlu2). The compounds and pharmaceutical compositions including the compounds may be useful for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.
