蛋白質體抑制劑及使用其之方法农业专利-农业学术服务平台

发明人:: OLIVA, AMBROGIO,安布洛吉欧奥立伐,安布洛吉歐奧立伐,BERNARDINI, RAFAELLA,拉法耶拉伯纳狄尼,拉法耶拉伯納狄尼,D'ARASMO, GERMANO,吉曼诺德拉斯莫,吉曼諾德拉斯莫,CASSARA, PAOLO G.,宝洛Ｇ　贾萨拉,寶洛Ｇ　賈薩拉,BERNAREGGI, ALBERTO,艾柏托伯纳雷吉,艾柏托伯納雷吉,MENTA, ERNESTO,尔内斯托曼塔,爾,DARASMO, GERMANO,宝洛G 贾萨拉,寶洛G 賈薩拉,爾內

摘要：: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.本發明提供可調節細胞凋亡之二羥基硼酸(boronic acid)化合物、二羥基硼酸酯及其組成物，例如經由抑制蛋白酶體活性。化合物及組成物可用於誘導細胞凋亡及治療例如癌症疾病及其他直接或間接與蛋白酶體活性有關失調之方法。