The present invention provides compositions containing one or more calcium sequestration agents and methods for topical application of such compositions to the skin to treat skin pigmentation disorders, such as melasma, post-inflammatory hyperpigmentation, pigmentation changes due to skin aging, or any other skin conditions related with normal such as skin of color or abnormal pigmentation such as hypo-or hyper-pigmentation in humans.本發明提供含有一或多種鈣螯合劑的組成物及將此等組成物局部施予皮膚以治療皮膚色素沈著病症的方法，諸如黑皮病、發炎後色素沈著過度、由於皮膚老化所致之色素沈著變化或任何與人類正常色素沈著(諸如膚色)或異常色素沈著(諸如色素沈著不足或過度)有關的其他皮膚病況。
