Joana Catarina Da Silva Correia,Joaquim Miguel Antunes De Oliveira,João Manuel Teixeira De Oliveira,Rui Pedro Amandi Romero De Sousa,Rui Luis Gonçalves Dos Reis
申请号：
US13637588
公开号：
US09012415B2
申请日:
2011.03.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions. The matrix can be used either as an acellular or cellular system, dispensed manually or automatically by injection and crosslinked directly at the site of application, and can be processed using manual or automated systems in different types of scaffolds, such as hydrogels, fibers, 3D structures and micro- or nanoparticles.
