SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION IN WHICH AN ELUTION STABILITY INCLUDING IMPROVED LEVETIRACETAM OR PHARMACEUTICALLY ACCEPTABLE SALT AND A MANUFACTURING METHOD THEREOF

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专利权人:

BIO PHARMARTIS CO.; LTD.

发明人:

LEE, SANG JOON,이상준,CHANG, KWAN YOUNG,장관영,AHN, JAE SOON,안재순,CHO, JAE MIN,조재민,KANG, KYOUNG UN,강경언,LEE, HYUN JOO,이현주

申请号：

KR1020100116988

公开号：

KR1020120055313A

申请日:

2010.11.23

申请国别(地区):

KR

年份:

2012

代理人:

摘要：

PURPOSE: A sustained-release pharmaceutical composition in which an elution stability including improved levetiracetam or pharmaceutically acceptable salt and a manufacturing method thereof are provided to improve compliance of medication object by reducing number of administration frequency and maintaining Inside concentration of active component within plasma.CONSTITUTION: A sustained-release pharmaceutical composition in which an elution stability including improved levetiracetam or pharmaceutically acceptable salt comprises a sustained release base including superabsorbent polymers and a pharmaceutically allowed excipient. The composition includes 50-90 weight% of levetiracetam or pharmaceutically acceptable salt based on total pharmaceutical composition. The superabsorbent polymer has viscosity of 50-100,000 mPa*s when the measurement is at 20 deg. Celsius in 2 weight% aqueous solution. The superabsorbent polymer is polyethylene oxide, hydroxypropyl cellulose, hydroxyethylcellulose, alginate, carbomer or a mixture thereof.COPYRIGHT KIPO 2012본 발명은 레베티라세탐 또는 이의 약학적으로 허용되는 염을 포함하는 서방형 약학 조성물 및 이의 제조방법에 관한 것으로, 보다 상세하게는 다양한 용출 조건 하에서 용출율의 변화가 없어 용출 안정성이 크게 개선된, 레베티라세탐 또는 이의 약학적으로 허용되는 염을 포함하는 서방형 약학 조성물과 상기 약학 조성물을 간단하고 용이한 공정으로 제조할 수 있는 개선된 제조방법에 관한 것이다.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/