Alan Berezov,Qiang Wang,Ramachandran Murali,Mark I. Greene
申请号：
US13142731
公开号：
US08710068B2
申请日:
2010.01.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV).
