ECCLESTON, Mark,VAINIKKA, Satu,MORRIS, George Steven
申请号：
AU2017225015
公开号：
AU2017225015B2
申请日:
2017.09.05
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2017225015B220190801.pdf#####ABSTRACT The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in 5 preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynaecological condition in which an activity of AR and/or ER is a contributory factor in a subject. Preferably, the molecule comprises or consists of the structure: N BJ[(Pro),-X-HisPro-His-Ala-Arg-le-Lys]m-Rp, or B[lys-ile-arg-ala-his-pro-his-xr-(pro),]m-Rp, or a derivative or 10 fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, mis an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro),] is the retro-inverso peptide of [(Pro)n,-Xr-His-Pro-His-Ala-Arg-Ile-Lys].
