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8–(1,3–דיהידרו–איזואינדול–2–איל–מתיל)–2,9–דיהידרו–1,2,7,9–טטראאז–פנאלן–3–און ותכשירים רוקחיים המכילים אותו
专利权人:
EISAI INC.
发明人:
申请号:
IL20477610
公开号:
IL204776A
申请日:
2010.03.28
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy- induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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