Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone or as drug conjugates with antibodies are provided. The tubulysin derivatives consist of a tetrapeptide scaffold comprising methyl and ethyl substituted piperidines. The tubulysin conjugates further comprise monoclonal antibody via succinimide linkers.Se proporcionan derivados de tubulisina novedosos que son útiles como agentes citotóxicos para proveer beneficios terapéuticos en el tratamiento de varios tipos de cáncer, solos, como conjugados de fármaco o en combinación con otras quimioterapias.
