Quinazoline heterocyclic compound as EGFR kinase inhibitor and preparation and application thereof

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专利权人:

BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

发明人:

Wang Sheng,Leifu Yang,Zhiyong Pan

申请号：

US15541026

公开号：

US10106508B2

申请日:

2016.01.12

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to an N-substituted-phenyl-5-substituted-alkoxy-2,3-dihydro-[1,4]dioxane[2,3-f]quinazolin-10-amine (I) or 4-substituted-arylamino-6-substituted-alkyl-6H-[1,4]oxazino[3,2-g]quinazoline-7(8H)-one (II) type compounds, a preparation method thereof and an application thereof as an inhibitor for epidermal growth factor receptor (EGFR) (comprising some mutant forms of EGFR) to treat cancer. These compounds and salts thereof can be used to treat or prevent various cancer diseases.

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