The present invention relates to novel derivatives of estradiol, in particular to deuterated derivatives of estradiol sulfamates. The present invention also relates to compositions comprising said novel derivatives, as well as to uses of said novel derivatives and compositions comprising said derivatives.Cette invention concerne de nouveaux dérivés dœstradiol, en particulier des dérivés deutérés de sulfamates dœstradiol. Linvention concerne également des compositions contenant lesdits nouveaux dérivés, ainsi que les utilisations desdits nouveaux dérivés et des compositions les contenant.