Controlled release oral dosage form comprising at least one portion that is rapidly disintegrating and at least one portion that is slowly disintegrating
LINDELL, KATARINA,THYRESSON, KRISTINA,NICKLASSON, FREDRIK,BUNICK, FRANK,LUBER, JOE,HUGERTH, ANDREAS
申请号：
NZ59171009
公开号：
NZ591710A
申请日:
2009.10.13
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a multi portion intra-oral dosage form where: at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion, and each portion comprises at least one item selected from the following items: a pharmaceutically active component, a nicotine mimicking component, a pH-buffering component, a pH-regulating component, a flavour, a barrier component, a colour component, an adhesive component, a taste masking agent, a tooth whitening agent, a breath freshening agent, an oral health promoting agent, an anti-caries agent, and an anti-inflammatory agent, and the rapidly disintegrating portion comprises at least 40 per cent by weight of a compressible excipient selected from isomalt, dextrose monohydrate, maltodextrin, lactose monohydrate, dextrin, mannitol, lactitol, sorbitol, xylitol, erythritol, sucrose, and lactose, and mixtures thereof, and the at least one rapidly disintegrating portion further comprises a water-swellable excipient selected from sodium starch glycolate, crospovidone, croscarmellose, microcrystalline cellulose, starches, hydroxypropyl cellulose, and alginic acid, the weight ratio of the compressible excipient to the water-swellable excipient is from about 10:1 to about 500:1.
