Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-alcoholic steatohepatitis and other diseases characterized by dysfunctional tissue healing and fibrosis.本文闡述化合物,包括其醫藥上可接受之鹽、溶劑合物、代謝物、前藥;製備該等化合物之方法;包含該等化合物之醫藥組合物;及使用該等化合物治療非酒精性脂肪性肝炎及其他特徵在於功能不良性組織癒合及纖維化之疾病的方法。