The present invention provides medicaments and methods for the treatment of melanoma. Disclosed herein are methods and uses for preventing melanoma, reducing progression of melanoma to a metastatic state, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral, enteral, or topical administration of autophagy modulator and a gap junction intercellular communication modulator to subjects indicated to be at risk due to factor(s) such as medical history of melanoma, excessive UV exposure, or those with stage II and III melanoma.
