Substituted tricyclic benzimidazoles as kinase inhibitors

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专利权人:

SELVITA SA

发明人:

Tomasz Rzymski,Adrian Zarebski,Agnieszka Dreas,Karolina Osowska,Katarzyna Kucwaj,Joanna Fogt,Marek Cholody,Michal Galezowski,Wojciech Czardybon,Raymond Horvath,Katarzyna Wiklik,Mariusz Milik,Krzysztof

申请号：

US14441785

公开号：

US09745299B2

申请日:

2013.11.07

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hemathological malignancies, autoimmune diseases and inflammatory diseases. Also disclosed are processes for preparing these compounds.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/