Institute for Cancer Research d/b/a/ The Research Institute of Fox Chase Cancer Center;Institut Curie;Institut de Génétique et de Biologie Moléculaire et Cellulaire
发明人:
Alfonso Bellacosa,Rossella Tricarico,Tim Yen,Vikram Bhattacharjee,Pietro Mancuso,Lionel Larue,Irwin Davidson
申请号：
US15084680
公开号：
US20160199381A1
申请日:
2016.03.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
