Thomas Kessler,Jörg Breitenbach,Christoph Schmidt,Matthias Degenhardt,Jörg Rosenberg,Harald Krull
申请号：
US14094563
公开号：
US09205027B2
申请日:
2013.12.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).
