The present disclosure provides a probiotics composition comprisingLactobacillus caseiculture,Lactobacillus plantarumculture,Lactobacillus paracaseiculture and pharmaceutically acceptable topical excipient. The present disclosure also provides use of the probiotics composition in the manufacture of a medicament of the treatment of skin diseases.本發明提供一種益生菌組合物,其包含乾酪乳酸桿菌培養物、胚芽乳酸桿菌培養物、副乾酪乳酸桿菌培養物及醫藥上可接受之外用賦形劑。本發明亦提供一種前述益生菌組合物之用途,其係用於製備治療皮膚病症之藥物。