The present invention relates to a method of manufacturing a sustained drug-release contact lens. More specifically, the present invention relates to a method of manufacturing a sustained drug-release contact lens, the method including: forming a body in which the body provides an outer shape of the lens and has a plurality of cavities configured to be recessed and spaced apart from each other by a predetermined distance along a side surface of the contact lens； and filling a drug and forming a closing part in which the cavities of the body formed at the forming the body are filled with the drug and respective closing parts closing the cavities are formed, wherein the closing part is made of a biodegradable material and each closing part is configured to open at a different time during wearing of the contact lens at the forming the body.
