THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
BARRANDON, ORNELLA,POGGIOLI, TOMMASO,MELTON, DOUGLAS A.,LEE, RICHARD T.
申请号：
CA3010799
公开号：
CA3010799A1
申请日:
2017.01.06
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed herein are a means to prevent and/or ameliorate age, disease and obesity associated metabolic diseases, such as diabetes and impaired glucose tolerance. Also disclosed are compositions and methods that relate to the findings that GDF11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis in aged mice administered a high fat diet. In particular, the methods and compositions described herein relate to increasing the level of GDF11 in a subject, thereby treating or preventing the development of obesity in the subject, reducing the metabolic consequences of obesity and improving the subject's metabolic health.
