AGONISTES QUI AMÉLIORENT LA LIAISON DES CELLULES EXPRIMANT L'INTÉGRINE AVEC DES RÉCEPTEURS DE L'INTÉGRINE

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专利权人:

Texas Heart Institute

发明人:

申请号：

EP18175796.4

公开号：

EP3388429A1

申请日:

2011.11.16

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the treated cells with an integrin-binding ligand； integrin agonist compounds having the general formula I； methods of treating integrin-expressing cells with such agonists to enhance binding； and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.

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