Composition comprises at least one chromium(III) compound, at least an algae extract or algae cells of Chlorella sp., and/or at least an algae extract or algae cells of Odontella sp.. An independent claim is included for a synergistic combination comprising chromium(III) compound, preferably chromium oxide, chromium chloride, chromium gluconate, chromium pyrolidone carboxylate, chromium orotate, chromium-EDTA complex, chromium sulfate, chromium nitrate, chromium acetate or chromium carbonate, and algae extract or algae cells of Chlorella sp.and/or Odontella sp.. ACTIVITY : Dermatological； Antiinflammatory； Antibacterial； Virucide； Cardiovascular-Gen.； Neuroprotective； Antidiabetic； Antiulcer； Gastrointestinal-Gen.； Respiratory-Gen. MECHANISM OF ACTION : Phosphodiesterase inhibitor； Triglyceride lipase inhibitor； Phosphoglycerate kinase inhibitor； Protein glycation inhibitor. The ability of the composition (comprising Chlorellaand chromium chloride) to inhibit the activity of phosphodiesterase was tested. The result showed that the composition exhibited IC 5 0value of 7.
