A positioning quick-release bioadhesion agent. Bio-compatible bioadhesion material is prepared into particles, a quick-release disintegrating agent is applied to the exterior thereof, and an enteric coating or a gastric coating is applied upon tabletting; or an enteric coating or a gastric coating is applied to the particles, or the particles are filled into an enteric soluble capsule or a gastric soluble capsule; or additive agents such as the bioadhesion material and the quick-release disintegrating agent are directly tabletted and applied with an enteric coating or a gastric coating. The positioning, quick-release bioadhesion agent is administered orally, and is easy to carry, store, and use.