An extracorporeal blood purification system with at least one extracorporeal blood purification apparatus, preferably dialysis machine, which is prepared to go through a centrally controlled disinfection process for a blood purification process, as well as with an internal fluid line system which is disinfected at least during the disinfection process by a disinfectant, including an internal or external disinfecting or cleaning case which is at least during the disinfection process via at least one case connection connected to the internal fluid conduit system to receive disinfectant.