High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
California Institute of Technology;University of Louisville Research Foundation, Inc.;The Regents of the University of California
发明人:
Edgerton, Victor Reggie,Roy, Roland R.,Gerasimenko, Yury,Burdick, Joel,Harkema, Susan J.,Hodes, Jonathan,Tai, Yu-Chong,Nandra, Mandheerej S.,Angeli, Claudia A.,Desautels, Thomas Anthony
申请号：
AU2016216735
公开号：
AU2016216735B2
申请日:
2016.08.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2016216735B220180412.pdf#####ABSTRACT Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor 5 disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time o electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
