LTD.;TOYAMA CHEMICAL CO., LTD.;TOYAMA CHEMICAL CO.
发明人:
NAKADA YASUSHI,YASUSHI NAKADA,NAKAGAWA MASAYA,MASAYA NAKAGAWA,ONO SATOSHI,SATOSHI ONO
申请号：
PL372934
公开号：
PL217394B1
申请日:
2003.04.03
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
An alkyl ether derivative represented by the formula: <；CHEM>； wherein R<；1>；, R<；2>；, R<；3>；, R<；4>；, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.
