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Method to Increase the Growth Velocity of Human Infants
专利权人:
Olle Hernell;Birgitta Olsson;Maria Öhman;Mårten Vågerö;Patrik Strömberg;Kristina Timdahl;Lennart Svensson
发明人:
Olle Hernell,Birgitta Olsson,Patrik Strömberg,Lennart Svensson,Kristina Timdahl,Mårten Vågerö,Maria Öhman
申请号:
US13278662
公开号:
US20120100126A1
申请日:
2011.10.21
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a method to increase the growth velocity of a human infant, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). Such method has particular utility for underweight or preterm human infants, particular those in medical need of increasing their growth velocity. The invention also relates to compositions, including infant feeds, kits, packaged-pharmaceutical-products and pharmaceutical compositions, and also to methods to prepare infant feeds. In another aspect, the present invention relates to methods to: (X) protect the small bowel mucosa of a human infant from damage; to (Y) protect an immature intestinal epithelium of a human infant from the deleterious effects of incompletely digested and/or excess fat and/or lipid; and/or to (Z) limit accumulation of incompletely digested and/or excess fat and/or lipid in the ileum of a human infant; said methods in each case comprising the step of enteral administration of rhBSSL.
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