LIANG, SHU MEI,杨淑美,楊淑美,CHIU, CHING FENG,邱庆丰,邱慶豐,HUNG, SHAO WEN,洪绍文,洪紹文,PENG, JEI MING,彭瑞铭,彭瑞銘,LIANG, CHI MING,梁启铭,梁啟銘
申请号：
TW099140291
公开号：
TWI426082B
申请日:
2010.11.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatmentin vitro.In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasisin vivowhile F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.本發明提供抑制癌症轉移之方法。癌症患者治療失敗及死亡之最常見原因即為癌症轉移。在活體外，原纖蛋白質(rVP1、F-HSA及F-BSA)的處理可顯著抑制腫瘤細胞侵入及/或移行。另外，在活體內，rVP1可顯著抑制老鼠及人類的乳癌轉移以及人類前列腺癌及卵巢癌的轉移，而F-HSA可顯著抑制老鼠乳癌轉移。本發明亦提供原纖蛋白質組合物及其使用方法用作抗癌症轉移治療之用。
