A multi-use bandage has a flexible fabric and a pouch forming a medication insert area located on an underside of the flexible fabric. The medication insert area is configured for overlying a treatment area on a user and for receiving therein any of a plurality of different medications for treating any of a plurality of different symptoms. An adhesive is located on an underside of the flexible fabric and surrounds the medication insert area. The adhesive is configured for adhesively engaging the users skin about the treatment area, and for preventing medication inserted in the medication insert area from spreading or moving from the treatment area to an unselected area of treatment.