CELLULES PROGÉNITRICES D'OLIGODENDROCYTE ISSUES DE CELLULES PLURIPOTENTES INDUITES POUR LE TRAITEMENT DE TROUBLES DE LA MYÉLINE

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专利权人:

UNIVERSITY OF ROCHESTER

发明人:

GOLDMAN, STEVEN, A.,WANG, SU

申请号：

EP14749594

公开号：

EP2954046A4

申请日:

2014.02.06

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present disclosure relates to a preparation of CD140a/PDGFRα positive cells that comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFRα. The preparation of cells is derived from pluripotent cells that were derived from skin cells, fibroblasts, umbilical cord blood, peripheral blood, bone marrow, or other somatic cells. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5+/PSA-NCAM−sorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of making, isolating and using the disclosed cell preparation are also described.

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