Jason David Oliver,John Leslie Thain,Michael John Bromley,Graham Edward Morris Sibley,Michael Birch
申请号：
US12990478
公开号：
US09034887B2
申请日:
2009.05.01
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
