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Freeze-Dried Plasma Formats for the Trauma Care Field
专利权人:
Irina B. Bakaltcheva
发明人:
Irina B. Bakaltcheva
申请号:
US13719596
公开号:
US20130122107A1
申请日:
2012.12.19
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Disclosed are freeze-dried plasma formats specifically designed for the trauma care field. Blood plasma is subjected to a glucose removal step, a protein fraction up-concentration step and addition of stabilizers prior to freeze-drying. Preferable stabilizers are glutamine dipeptides, glutamine and glycine. The glutamine based formulation is added direct to plasma and serves three main purposes: 1) Increases stability of plasma proteins and stabilizes pH in freeze-dried state; 2) Increases stability of plasma proteins against Gamma Irradiation and thus allows for the application of a terminal sterilization step; 3) Introduces supplements beneficial to the trauma patient.
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