Jeffrey Kroll Adams;Robert E. Zipkin;Sarah Spiegel
发明人:
Robert E. Zipkin,Sarah Spiegel,Jeffrey Kroll Adams
申请号：
US12387228
公开号：
US08372888B2
申请日:
2009.04.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis.
