PROBLEM TO BE SOLVED: To provide compounds having a V2 receptor activation effect among arginine vasopressin receptors (V1a, V1b, and V2), and preventive or therapeutic agents based on the V2 receptor activation effect for central diabetes insipidus, enuresis, nocturia, overactive bladder, hemophilia, or von Willebrand disease.SOLUTION: Provided is a pharmaceutical composition comprising benzoazepine derivatives having structures represented by formula (I) and pharmacologically acceptable salts thereof as active ingredients. (Ris an alkyl and the like； Ris an alkyl and the like； Ris a heterocyclic 5-membered ring； and Ris H and the like.)SELECTED DRAWING: None【課題】アルギニンバソプレシン受容体（Ｖ１ａ、Ｖ１ｂ、Ｖ２）の内のV2受容体作動作用を有する化合物、及び、V2受容体作動作用に基づく、中枢性尿崩症、夜尿症、夜間頻尿、過活動膀胱、血友病、又はフォンウィルブランド病の予防又は治療剤の提供。【解決手段】式（Ｉ）で表される構造を有するベンゾアゼピン誘導体、及び、その薬理学的に許容される塩を有効成分とする医薬組成物。（Ｒ２はアルキル等；Ｒ３はアルキル等；Ｒ４はヘテロ５員環；Ｒ５はＨ等）【選択図】なし
