Compositions, methods, and devices are herein disclosed for anti-sneeze and nose vestibule care for humans and other animals. An anti-sneeze composition includes an adrenergic agent, an anticholinergic agent, an antihistamine, a plasticizer for nose skin/nose muscle, and a soothing agent. A version of nose vestibule care composition includes alternative functional agents, such as anti-inflammatory agents, anti-oxidants, and antimicrobials, besides adrenergic, anticholinergic, and antihistamine agents. The alternative or additional agents are present in the invented composition for the purposes of wellness care of noses, prevention of diseases or aiding a medical treatment. The methods and devices for delivering the compositions to the nose vestibules for anti-sneeze, for wellness care, preventive care measure against diseases, and for aiding medical treatment of diseases are prescribed.
