ALEX BALDUINO DE SOUZA,BRENO VALENTIM NOGUEIRA,CARLOS MAGNO DA COSTA MARANDUBA,DANIELLE LUCIANA AURORO SOARES DO AMARAL,JAIRO PINTO DE OLIVEIRA,RODOLPHO JOSÉ DA SILVA BARROS
申请号：
BR102018003726
公开号：
BR102018003726A2
申请日:
2018.02.26
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
It is a biomaterial developed from decellularized animal bone tissue and coated with an extracellular bone matrix in the form of a gel, capable of providing efficient mechanical and biological support, as well as being enriched with cell lines, nanocomposites or drugs. when used as a bone graft, bioreactor, or vehicle in the treatment, research, and development of other biomaterials； that is, it was developed from decellularized, lyophilized, porous and rigid, manipulable, safe and non-immunogenic bone material, coated and enriched with bone tissue stimulating substances, presented / used in particulate or block form. ability to promote the development of mature or progenitor cell lines in vitro when used as a bioreactor, and demonstrates high integration capacity and faster fracture healing and bone defect filling when used as an in vivo graft； The biomaterial also allows the cell development to be favored by maintaining the integrity of the organic extracellular matrix of bone tissue, being able to improve healing time, reduce costs and scientifically contribute to basic research demonstrating the biotechnological importance, the investigative need and applicability of decellularized organic matrices in biomaterials.trata- se de um biomaterial desenvolvido a partir de tecido ósseo animal descelularizado e revestido com matriz extracelular óssea na forma de gel, que seja capaz de conferir eficiente suporte mecânico e biológico, e que permita ainda ser enriquecido com linhagem de células, nanocompostos ou fármacos, quando utilizado como enxerto ósseo, biorreator, ou veículo em tratamentos, pesquisas e desenvolvimento de outros biomateriais； ou seja, foi desenvolvido a partir de material ósseo descelularizado, liofilizado, poroso e rígido, manipulável, seguro e não imunogênico, revestido e enriquecido com substâncias estimulantes próprias do tecido ósseo, apresentado/utilizado na forma particulada ou em bloco, assim, possui a capacidade de promover o desenvolvimento
