The present disclosure provides a method of modulating protein expression from a Mena-ribonucleoprotein (RNP) complex, the method comprising administering to a subject an agent that: (a) inhibits protein expression by inhibiting Mena translation, Mena transcription, or the association of Mena with the Mena-RNP complex, or (b) promotes protein expression by: (i) inhibiting the expression of at least one of HnmpK, PCBP1, or both, or (ii) dissociating at least one of HnmpK, PCBP1, or both, from the Mena-RNP complex in the cell. The present disclosure also provides a method of ameliorating, treating, or preventing at least one symptom of a disease, disorder, or syndrome associated with the overexpression or accumulation of DYRK1A and/or amyloid precursor protein (APP) in cells, as well as a method of ameliorating, treating, or preventing at least one symptom of a disease, disorder, or syndrome associated with the underexpression DYRK1A in cells.
