Geoffrey DE BILDE,Pierre SACRE,Jonathan GOOLE,Karim AMIGHI,Olivier LALOUX,Georges GUILLAUME,Vincent STEPHENNE
申请号：
US16825873
公开号：
US20200315978A1
申请日:
2020.03.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A controlled-release multilayer microparticle containing a pharmaceutically active compound, which is intended for oral administration or direct administration in the stomach, which may be done using a liquid pharmaceutical composition containing the microparticle. The microparticle may include: a core that includes the pharmaceutically active compound, which may be pramipexole； a controlled-release intermediate coating layer； and an outmost external protection coating layer surrounding the controlled-release intermediate coating layer. The external protection coating layer may include a mixture of: a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5； and a hydrophobic and/or insoluble component. Also disclosed are a liquid pharmaceutical composition containing the microparticles, a kit for the preparation of the liquid pharmaceutical composition, a pharmaceutical solid composition reconstitutable as the liquid composition, a process of preparing the liquid composition, and a method for treating disease with the liquid composition.
