ФРАНКЛИН Ричард (GB),ГОЛДИНГ Бернард Т. (GB),ТАЙСОН Роберт Дж. (GB)
申请号：
RU2012106605/04
公开号：
RU2012106605A
申请日:
2010.07.23
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. The compound of Formula 1: Formula 1 or a pharmaceutically acceptable salt thereof, wherein R is H, or； R is H, CH, or； each R is independently hydrogen, substituted by an alkyl group or unsubstituted alkyl group； each R, R, R, and R is independently selected from hydrogen ,, substituted alkyl group or unsubstituted alkyl group； each n is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16； each n is independently 1, 2, 3, 4, 5, 6, 7, 8, or 9； each n is independently 0 or 1； each n is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11, 12, 13, 14, 15 or 16； each th n is independently 0 or 1； each R is independently a side chain of a proteinogenic or non-proteinogenic amino acid； each X is independently (-NH-), (-O-) or absent； each X ′ is independently (-NH-), (-O- ) or absent； each Y is independently or； each Cy is independently a 5- or 6-membered cycloalkyl, 5- or 6-membered heterocycle, 5- or 6-membered aryl, or 5- or 6-membered heteroaryl, where Cy is optionally fused with a second ring, which is a 5- or 6-membered heterocyclic, 5- or 6-membered cycloal yl, 5- or 6-membered aryl or a 5- or 6-membered heteroaryl koltso.2. The compound according to claim 1, where R is,, or； R is, or. A compound according to claim 2, wherein each R is independently an amino acid side chain of valine, phenylalanine, tryptophan or tyrosine. The compound according to claim 3, where R is CH； n is 1； and each R is independently H or an alkyl group； and R 1 is the amino acid side chain of valine. 5. The compound of claim 4, wherein R is CH； n is 1； and R is H.6. The compound of claim 2, wherein X is absent. 7. Connection1. Соединение Формулы 1:Формула 1или его фармацевтически приемлемая соль, гдеRявляется H,или；Rявляется H, CH,или；каждый Rявляется независимо водородом, замещенной алкильной группой или незамещенной алкильной группой；каждый R, R,R, и Rявляется независимо выбранным из водорода,, замещенной алкильной группы или незамещенной алкильной группы；каждый nя
