A retractable-type safe self-locking-type self-destructing syringe, which comprises a syringe barrel body (6). A plunger (7) is arranged in the syringe barrel body (6). A needle base is arranged in a barrel neck at an end part of the syringe barrel body (6). A sealing ring (3) is sleeved on the outer wall of the needle base. A head part for needle replacement is formed by the upper part of the needle base. A flexible support engaging piece (4) is arranged within a cavity at the lower part of the needle base. A locking-clutching mechanism matching the end part of the plunger (7) is arranged within the flexible support engaging piece (4).