LEVENGOOD, MATTHEW R.,利文格 马修 R,利文格 馬修 R,利文格 马修 R,利文格 馬修 R
申请号：
TW106144020
公开号：
TW201827085A
申请日:
2017.12.14
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present disclosure provides,inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units, that are constructed in a site-specific matter via ‘orthogonal’ deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.本發明尤其提供多重藥物之抗體藥物結合物(MD-ADCs)及連接組裝(LA)單元，該等係以位點特異性方式經由「正交」去保護及藥物加載進行構築。亦提供經保護之連接組裝單元，該等單元容許本發明之MD-ADCs及LA單元進行「正交」去保護及構築。
