A novel mesenchymal stem cell cell aging inhibitor capable of effectively suppressing mesenchymal stem cell cell aging, and a mesenchymal stem cell cell aging inhibitor using the mesenchymal stem cell cell aging inhibitor Provided are a skin external composition for use, a functional food or drink for inhibiting cell senescence of mesenchymal stem cells, and a method for inhibiting cell senescence of mesenchymal stem cells. A mesenchymal stem cell cell aging inhibitor comprising astaxanthin and tocopherol nicotinate as active ingredients, and a skin external composition for inhibiting mesenchymal stem cell cell aging using the mesenchymal stem cell cell aging inhibitor , A functional food or drink for inhibiting cell senescence of mesenchymal stem cells, and a method of inhibiting cell senescence of mesenchymal stem cells. [Selection diagram] None【課題】間葉系幹細胞の細胞老化を効果的に抑制可能な新規な間葉系幹細胞の細胞老化抑制剤、並びにその間葉系幹細胞の細胞老化抑制剤を用いた間葉系幹細胞の細胞老化抑制用皮膚外用組成物、間葉系幹細胞の細胞老化抑制用機能性飲食品、及び間葉系幹細胞の細胞老化抑制方法を提供する。【解決手段】アスタキサンチン及びニコチン酸トコフェロールを有効成分として含有する間葉系幹細胞の細胞老化抑制剤、並びにその間葉系幹細胞の細胞老化抑制剤を用いた間葉系幹細胞の細胞老化抑制用皮膚外用組成物、間葉系幹細胞の細胞老化抑制用機能性飲食品、及び間葉系幹細胞の細胞老化抑制方法。【選択図】なし