Gray, Peter C.,Shani, Gidi,Kelber, Jonathan A.,Vale, Wylie
申请号：
AU2009313255
公开号：
AU2009313255B2
申请日:
2009.11.09
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides methods compositions and methods for treating a hyperproliferative disease comprising disrupting Cripto/GRP78 complex formation in a hyperproliferative cell. In certain embodiments, an antibody and/or siRNA may be used to inhibit Cripto/GRP78 binding, optionally coupled with other cancer therapies. Also provided are methods for identifying therapeutic compounds which can selectively inhibit Cripto/GRP78 binding.
