Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration

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专利权人:

Amgen Inc.

发明人:

Abel, Jeff,Cui, Lingwen,Goswami, Devrishi,Huh, Joon,Jagannathan, Bharadwaj,Kanapuram, Sekhar,McAuley, Arnold,Schneider, Michael,Sethuraman, Ananthakrishnan G.,Treuheit, Michael,Zhang, Jun

申请号：

AU2018261951

公开号：

AU2018261951A1

申请日:

2018.05.07

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.

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中国工程科技知识中心

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http://www.ckcest.cn/home/