Depression constitutes the second most common chronic condition in clinical practice. About 21% of the world population is affected by this disorder. Current drugs which are used to treat depression have severe side effects and long term treatment process. A polyherbal formulation was developed for treatment of depression comprises the ten medicinal plants (at least six) namely Baccopa monneri, Plumbago Zylanica, Capparis Zeylanica, Glossocardia bosvellia, Hemidesmus indicus, Ocimum sanctum, Withania somnifera, Mimosa pudica, Asparagus recemosus and Tinospora cordifolia are mixed in desired quantity to make 100 g mixture. The 10 g of above mixture has been orally adminstered daily morning and evening up to six months to treat depression. The polyherbal formulation is simple, easy to prepare, safer and alternative method of treatment for depression.