The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.La présente invention concerne un composé de dérivé de biguanide pouvant prévenir et traiter efficacement des maladies immunitaires. Le composé de dérivé à base de biguanide selon la présente invention empêche la génération de IL-17 et TNF-α, qui sont des cytokines inflammatoires, augmente lactivité de lymphocytes T régulateurs ayant une fonction immunomodulatrice, et présente dexcellents effets thérapeutiques chez des modèles animaux atteints de maladies immunitaires. Par conséquent, le composé de dérivé à base de biguanide peut être utilisé efficacement comme immunosuppresseur ou comme composition pharmaceutique pouvant prévenir ou traiter diverses maladies immunitaires, telles que des maladies auto-immunes, des maladies inflammatoires et un rejet de greffe, causées par le dérèglement des réponses immunitaires.본 발명은 면역질환을 효과적으로 예방 및 치료할 수 있는 바이구아나이드(biguanide) 유도체 화합물에 관한 것이다. 본 발명의 바이구아나이드계 유도체 화합물은 염증성 사이토카인인 IL-17 및 TNF-α의 생성을 억제시키며, 면역조절 기능을 갖는 조절 T 세포의 활성을 증대시킬 뿐만 아니라, 면역질환 동물모델에 대해 우수한 치료 효과를 나타낸다. 따라서 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용될 수 있다.
