Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Institut fiziki poluprovodnikov im. A.V. Rzhanova Sibirskogo otdeleniya Rossijskoj akademii nauk (IFP SO RAN)
发明人:
Prints Viktor Yakovlevich,Принц Виктор Яковлевич,Seleznev Vladimir Aleksandrovich,Селезнев Владимир Александрович,Prints Aleksandr Viktorovich,Принц Александр Викторович
申请号：
RU2015155709
公开号：
RU0002622009C1
申请日:
2015.12.25
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention is a method to form a bioresorbable polymeric cellular matrix for tissue regeneration, which consists in litographic production of a set of two-dimensional matrices in the form of a polymer film with superficial arrays of micro- and nanoobjects, which for each two-dimensional matrix are performed with individual architecture, systemicity and interconnection of micro- and nanoobjects location in the architecture, with a possibility of specifying the bone tissue structure to be formed, taking into account its biological functions, with a possibility of providing mechanical support, controlling the cell differentiation and proliferation processes, then the two-dimensional matrices are assembled into a supporting framework for cell cultures and biological agents, orienting them relative to each other with a possibility of specifying the bone tissue structure and fixing a stack, while difference is that the assembly is performed in liquid medium hardened to a bioresorbable material at photoexposure, two-dimensional matrix are sequentially set against each other with a gap, in which during successive installation layers of bioresorbable polymer are obtained by projection three-dimensional printing using a digital projector the layers contain arrays of microscopic objects with individual architecture, system and interconnectivity of their location in the architecture, ability to specify the external form and internal three-dimensional matrix structure according to the three-dimensional computer model of the bone, with a possibility to provide mechanical support, cell proliferation and differentiation process control in the orthogonal direction relative to the surface of the two-dimensional matrices.EFFECT: improved accuracy of structure imitation, of tissue being formed, achieved imitation accuracy in three dimensions, setting of the three-dimensional shape of matrix imitating the bone, based on a three-dimensional computer model of
